CA-074 ME
CA-074 ME
CAS: 147859-80-1
Molecular Formula: C19H31N3O6
CA-074 ME - Names and Identifiers
CA-074 ME - Physico-chemical Properties
| Molecular Formula | C19H31N3O6 |
| Molar Mass | 397.47 |
| Density | 1.212±0.06 g/cm3(Predicted) |
| Melting Point | 153-155°C |
| Boling Point | 666.3±55.0 °C(Predicted) |
| Solubility | Soluble in DMSO |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 13.38±0.40(Predicted) |
| Storage Condition | -20°C |
| In vitro study | CA-074Me inhibits cathepsin L in HL-60 cells and in the blood form of Trypanosoma brucei, but does not act in the absence of thiols. CA-074Me is transformed into CA-074 under the action of intracellular esterases and thus inhibits cathepsin B in GSH-depleted HL60 cells. CA-074, but not CA-074Me, selectively inhibits cathespsin B in living cells. Myotube size, number, and induced fusion-related creatine phosphokinase activity and myosin heavy chain protein were reduced in CA074Me-treated myoblasts, and the degree of reduction correlated with concentration. In differentiating myoblasts, micromolar concentrations of CA-074Me inhibit catB activity. |
| In vivo study | Administration of CA074Me to London APP mice significantly improved their memory deficits, reduced the levels of amyloid plaque load, Aβ40 and Aβ42 in the brain, and reduced APP-derived ctfβ. There was no such effect in Swedish/London APP mice. Intraventricular injection of CA074Me in normal guinea pigs resulted in A large decrease in intracerebral Aβ and inhibition of β-secretase activity. |
CA-074 ME - Risk and Safety
| WGK Germany | 3 |
CA-074 ME - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.516 ml | 12.58 ml | 25.159 ml |
| 5 mM | 0.503 ml | 2.516 ml | 5.032 ml |
| 10 mM | 0.252 ml | 1.258 ml | 2.516 ml |
| 5 mM | 0.05 ml | 0.252 ml | 0.503 ml |
Last Update：2024-01-02 23:10:35
CA-074 ME - Reference Information
| biological activity | CA-074 methyl ester (CA-074 Me, Cathepsin B Inhibitor IV) is a CA-074 derivative of permeable membranes, it is an irreversible inhibitor of cathepsin B. |
| Target | Value |
Last Update：2024-04-09 21:54:55
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Spot supply
Product Name: CA-074 ME Visit Supplier Webpage Request for quotationCAS: 147859-80-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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